Enrica Pellegrino

A single-donor iPSC-derived alveolar chip with epithelial, endothelial and macrophage cells models early Mycobacterium tuberculosis infection and shows ATG14-deficient macrophages die more without extra bacterial replication.

The paper shows ATG9A and ARFIP2 work together to regulate PI4P levels for lysosomal repair during damage and bacterial infection.

The paper develops an all-RNA prime editing system achieving over 95% editing efficiency in human iPSCs with minimal off-target effects.

This study shows that WDR62 mutations disrupt Golgi-to-spindle pole shuttling in neural progenitors, leading to neurodevelopmental abnormalities in microcephaly.