Adrenergic signaling induces a pro-tumorigenic B cell state in colorectal cancer
Meike S. Thijssen, Simone L. Schonkeren, Linde Coolkens, Yuchi Zou, Lieve Temmerman, Joëlle de Vaan, Musa Idris, Jorunn Vranken, Kim Wouters, Nathalie Vaes, Marion J. Gijbels, Sharon Scardellato, Erwin Wijnands, Willine J. van de Wetering, Frank Verhaegen, , Veerle Melotte
This study shows adrenergic signaling promotes a pro-tumorigenic B cell state in colorectal cancer by altering their transcriptome and function, linking neuronal activity to immune responses and patient survival.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology