Leal Herlitz

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

The paper uses Digital Spatial Profiling to analyze transcript localization in renal transplant biopsies, showing compartmentalized immune responses and persistent podocyte transcript reduction during antibody-mediated rejection.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.