David Wang

Blockade of Interleukin-6 (IL-6) Signaling in Dedifferentiated Liposarcoma (DDLPS) Decreases Mouse Double Minute 2 (MDM2) Oncogenicity via Alternative Splicing

This study shows that blocking IL-6 signaling in DDLPS reduces MDM2 oncogenicity through alternative splicing, suggesting a potential therapeutic target.

Novel murine model of human astrovirus infection reveals a cardiovascular tropism

This paper develops a novel murine model of human astrovirus infection, revealing a cardiovascular tropism and immune response mechanisms.

Serosurveillance and first detection of Bourbon virus RNA in a wildlife host

The paper detects BRBV RNA in a coyote and identifies seropositive wildlife species in St. Louis, linking tick density and host composition to BRBV exposure.

Barcoded SARS-CoV-2 viruses define the impact of time and route of transmission on the transmission bottleneck in a Syrian hamster model.

This study uses barcoded SARS-CoV-2 viruses in Syrian hamsters to show that transmission bottleneck varies by exposure duration and route, with direct contact having the largest bottleneck.

Dengue Virus Surveillance in Nepal Yields the First On-Site Whole Genome Sequences of Isolates from the 2022 Outbreak

The paper reports the first on-site whole genome sequencing of dengue virus isolates from Nepal's 2022 outbreak, identifying DENV1, 2, and 3 and linking them to sequences from India and China.

Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial host, Bacteroides cellulosilyticus WH2

This study isolates and characterizes three novel Crassvirales phages infecting Bacteroides cellulosilyticus WH2, revealing they do not co-evolve with their hosts and share a conserved tail spike protein involved in host interaction.

An Intracellular Pathogen Response Pathway Promotes Proteostasis In C. elegans

This study identifies a novel pathway, the Intracellular Pathogen Response (IPR), that promotes proteostasis in C. elegans by upregulating ubiquitin ligase components like cul-6, with pals-22 acting as a repressor.