Author

Gian Marco Leggio

University of CataniaORCID 0000-0002-7280-4871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandra RaioiD· 1 shared Alessandro BertolinoiD· 1 shared Alessia Forgiarini· 1 shared Alessio Maria MonteleoneiD· 1 shared Andreas HeinziD· 1 shared Antoine GrigisiD· 1 shared Antonella Lupo· 1 shared Antonio RampinoiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alessandra RaioORCID

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2 papers

Recent·Most cited

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

Nicola Sambuco, Antonella Lupo, Peter C.T. Hawkins, Pierluigi Selvaggi, Linda Antonella Antonucci, Alessandro Bertolino, Giuseppe Blasi, Piergiuseppe Di Palo, Luigi Grassi, Daniela Grasso, Philipp Homan, Gian Marco Leggio, Francesco Massari, Alessio Maria Monteleone, Martin Osugo, , Giulio Pergola

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

Nature Communications · Sep 3, 2026Peer-reviewedNeuroscience

Astrocytic Regulation of Basal Ganglia Dopamine/D2-Dependent Behaviors

Rosa Mastrogiacomo, Gabriella Trigilio, Daniel Dautan, Céline Devroye, Valentina Ferretti, Enrica Vitali, Genny Orso, Roberto Marotta, Federica Maltese, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Debora A. Rothmond, John L. Waddington, Filippo Drago, , Francesco Papaleo

This study shows that astrocytic Dys1A hypofunction disrupts dopamine dynamics and leads to motivational and sensorimotor gating deficits in the basal ganglia.

bioRxiv · May 11, 2021 · PreprintNeuroscience