Giulio Pergola

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

Liquidity of gene co-expression trajectories across the lifespan highlights delayed maturation and the perinatal GABA switch in schizophrenia risk

The paper uses a novel 'liquidity' metric to analyze gene expression trajectories across lifespan, revealing delayed maturation and perinatal GABA switch in schizophrenia risk without detectable neuropathology.

Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance

The paper examines how schizophrenia genetic risk and resilience variants, co-expressed in the human brain, are associated with cognitive performance across development in 16,520 individuals.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.

Rare schizophrenia risk variant burden is conserved in diverse human populations

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

A Biologically Interpretable Graph Convolutional Network to Link Genetic Risk Pathways and Neuroimaging Phenotypes of Disease

This paper introduces a graph convolutional network that links genetic risk pathways with neuroimaging phenotypes in schizophrenia, achieving better classification performance than existing methods.

Investigating trait variability of gene co-expression network architecture in brain by manipulating genomic signatures of schizophrenia risk

The paper manipulates genomic risk signatures for schizophrenia in brain co-expression networks to explore their impact on gene connectivity and variability.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Genetic control of variability in subcortical and intracranial volumes

The paper identifies genetic loci associated with variability in brain volumes and thickness, showing they are distinct from loci affecting mean volumes.

Genetics of brain age suggest an overlap with common brain disorders

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia

The paper shows working memory involves brain-wide state switching, with dopamine D1/D2 receptor expression affecting stability and state transitions, and schizophrenia linked to altered network control properties.

Prefrontal co-expression of schizophrenia risk genes is associated with treatment response in patients

The paper identifies a gene co-expression module enriched for schizophrenia risk genes and shows its association with treatment response in schizophrenia patients.

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

This study identifies 15 genome-wide significant loci associated with hippocampal subfield volumes in 21,297 individuals, revealing distinct genetic determinants for different subfields.

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

This paper investigates brain structural heterogeneity in schizophrenia and finds that polygenic risk is associated with thinner fronto-temporal cortices and smaller hippocampal subfields, but not with increased variability.