Spatial single cell transcriptomic analysis of a novel DICER1 Syndrome GEMM informs the cellular origin and developmental hierarchy of associated sarcomas
Felix K. F. Kommoss, Joyce Yu Han Zhang, Branden J. Lynch, Shary Yuting Chen, Janine Senz, Yana Moscovitz, Lesley A. Hill, Ding Ma, R. Wilder Scott, Jonathan W. Bush, Kenneth Sung-Man Chen, Andrew J. L. Roth, Andreas von Deimling, William David Foulkes, Gregg B. Morin, , David D. Huntsman
This study uses a mouse model to identify a fibroblastic origin for DICER1 sarcomas and shows their potential to differentiate into rhabdomyoblastic or anaplastic sarcomas.
Nature Communications · Mar 30, 2026Peer-reviewedCancer Biology