Author

Branden J. Lynch

BC Cancer AgencyORCID 0009-0008-4564-8894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:software / tool· 2 Assay:whole-genome sequencing· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:deconvolution· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

David D. HuntsmaniD· 3 shared Ding Ma· 3 shared Andrew J. L. RothiD· 2 shared Janine SenziD· 2 shared Sheila Nicholson· 2 shared Alexandre Bouchard‐CôtéiD· 1 shared Andreas von DeimlingiD· 1 shared Carlos Vasquez-RiosiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

David D. HuntsmanORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 19, 2026

✦ In-depth digest

Minimally invasive monitoring of clonal evolution through integrated single cell and ctDNA analysis

Farhia Kabeer, Matteo Lepur, Branden J. Lynch…·Andrew J. L. Roth

cfClone, a Bayesian model, deconvolves cfDNA whole-genome sequencing using scWGS-derived haplotype-specific clone copy-number profiles to estimate tumour fraction, clonal prevalence, and flag missed clones.

DOI 10.64898/2026.07.29.741620

humanwhole-genome sequencing

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJul 27, 2026

Utanos: A general-purpose shallow whole-genome sequencing analysis workflow identifies interpretable copy number signatures

J. Maxwell Douglas, Branden J. Lynch, Jacky Chun Hei Yiu…·Yongjin Park

Utanos provides a modular workflow for analyzing shallow whole-genome sequencing data to detect copy number aberrations and signatures.

DOI 10.64898/2026.07.22.739009

whole-genome sequencingexperimental assay

𝕏 PostBluesky

Cancer BiologyNature CommunicationsPeer-reviewedMar 30, 2026

Spatial single cell transcriptomic analysis of a novel DICER1 Syndrome GEMM informs the cellular origin and developmental hierarchy of associated sarcomas

Felix K. F. Kommoss, Joyce Yu Han Zhang, Branden J. Lynch…·David D. Huntsman

This study uses a mouse model to identify a fibroblastic origin for DICER1 sarcomas and shows their potential to differentiate into rhabdomyoblastic or anaplastic sarcomas.

1 citation

mousescRNA-seq

𝕏 PostBluesky