David D. Huntsman

cfClone, a Bayesian model, deconvolves cfDNA whole-genome sequencing using scWGS-derived haplotype-specific clone copy-number profiles to estimate tumour fraction, clonal prevalence, and flag missed clones.

The paper uses multi-omic single-cell spatial techniques to study FL transformation, finding spatial shifts in B-cell neighborhoods and immunomodulatory interactions linked to disease progression.

Utanos provides a modular workflow for analyzing shallow whole-genome sequencing data to detect copy number aberrations and signatures.

This study uses a mouse model to identify a fibroblastic origin for DICER1 sarcomas and shows their potential to differentiate into rhabdomyoblastic or anaplastic sarcomas.

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

The paper identifies novel genetic mechanisms underlying missing heritability in HDGC-like families by integrating chromatin accessibility, promoter interactions, and whole-genome sequencing data.

This study identifies seven novel genetic loci associated with high-grade serous ovarian cancer risk using a large-scale GWAS and develops polygenic scores for improved risk prediction.

This study profiles single-cell transcriptomes of endometriosis subtypes to identify transcriptional differences and associations with ovarian cancer.

This study uses GANs to synthesize high-resolution cancer pathology images, showing they are visually indistinguishable from real images and perform as well as real images in diagnostic tasks.