Shane Denecke

An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics

This paper develops an insectified Caco-2 cell line to study pesticide transport and pharmacokinetics, showing differential efflux kinetics across insect and human P-gp homologs.

Functional characterization of putative ecdysone transporters in lepidopteran pests

This paper functionally characterizes OATP74D as an essential ecdysone transporter in two lepidopteran pests, showing its role in development and gene regulation.

Genetic characterization of ABC pesticide transporters establishes Drosophila as an in vivo model for toxicogenetics

This study characterizes ABC pesticide transporters in Drosophila to establish it as a model for toxicogenetics, identifying key transporters involved in pesticide sensitivity.

Partitioning The Roles Of Insect And Microbial Enzymes In The Metabolism Of The Insecticide Imidacloprid In Drosophila melanogaster

The paper investigates the roles of insect and microbial enzymes in imidacloprid metabolism in Drosophila melanogaster using genetic and mass spectrometry methods, finding microbial contributions to nitro-reduced metabolites and excretion of toxic products.

Multiple P450s And Variation In Neuronal Genes Underpins The Response To The Insecticide Imidacloprid In A Population Of Drosophila melanogaster

The paper investigates genetic factors underlying imidacloprid resistance in Drosophila melanogaster using genomic and transcriptomic data, identifying Cyp6g1 and Cyp6g2 as key contributors.