Spiros A. Pergantis

An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics

This paper develops an insectified Caco-2 cell line to study pesticide transport and pharmacokinetics, showing differential efflux kinetics across insect and human P-gp homologs.

Arsenite methyltransferase 3 regulates hepatic energy metabolism which dictates the hepatic response to arsenic exposure

This paper shows that As3mt regulates hepatic energy metabolism independently of arsenic detoxification, leading to mitochondrial dysfunction and fatty liver in zebrafish mutants.

High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest

This study identifies genetic variants, including copy number variation and cis-regulatory changes, associated with pyflubumide resistance in spider mites through high-resolution genetic mapping and functional experiments.