John G. VONTAS

This paper develops an insectified Caco-2 cell line to study pesticide transport and pharmacokinetics, showing differential efflux kinetics across insect and human P-gp homologs.

This study shows that combining different molecular mechanisms increases insecticide resistance in Anopheles gambiae, with implications for resistance management.

The study shows antibiotic-induced dysbiosis in Anopheles mosquitoes promotes deltamethrin tolerance via an Aeromonas taxon and P450-dependent detoxification.

The paper assesses insecticide resistance in Tunisian mosquitoes, identifying resistance mutations and suggesting control strategies.

This study assesses cross-resistance to transfluthrin in mosquitoes, showing resistance mechanisms reduce its efficacy in vector control.

This study identifies cannabidiol and its semisynthetic analogues as potential synergists to enhance insecticide efficacy against pyrethroid-resistant malaria mosquitoes.

This study assesses pesticide resistance in Tetranychus urticae and Bemisia tabaci in Greece using bioassays and ddPCR, revealing widespread resistance mutations and highlighting the need for integrated pest management.

dsRNAEngineer is a web tool for designing dsRNA molecules targeting pests while avoiding non-pest organisms, using transcriptome data to improve specificity and efficiency.

The paper develops and applies species identification and insecticide resistance assays to monitor sand fly vectors in the Mediterranean and Middle East, revealing resistance mutations and species-specific responses to insecticides.

This study identifies a genomic duplication of multiple P450 genes in Aedes aegypti that enhances deltamethrin resistance and reveals its evolutionary origin and fitness costs.

The paper identifies P450 enzymes responsible for pyrethroid resistance in Bactrocera oleae by comparing transcriptomes and testing enzyme activity.

This paper functionally characterizes OATP74D as an essential ecdysone transporter in two lepidopteran pests, showing its role in development and gene regulation.

The paper sequences and annotates the genomes of two sand fly species, identifying genes related to vector biology and population structure to aid in leishmaniasis control.

This study characterizes ABC pesticide transporters in Drosophila to establish it as a model for toxicogenetics, identifying key transporters involved in pesticide sensitivity.

This study identifies genetic variants, including copy number variation and cis-regulatory changes, associated with pyflubumide resistance in spider mites through high-resolution genetic mapping and functional experiments.

This paper reports successful CRISPR-Cas9-induced gene knock-outs in the spider mite Tetranychus urticae, demonstrating the feasibility of gene editing in chelicerates.

The paper develops a Gal4 driver line to fluorescently tag Anopheles gambiae oenocytes and shows two cyp4g genes are required for cuticular hydrocarbon synthesis.

This study identifies cuticle alterations and P450 detoxification as resistance mechanisms in pyrethroid-resistant Anopheles arabiensis populations from Ethiopia using RNAseq.