Gen Li

This study isolates and characterizes microbiota from human pancreatic tumors and small intestine, revealing how a Klebsiella oxytoca strain affects the tumor microenvironment and therapy response.

ADAPT improves microbiome differential abundance analysis by addressing zeros and compositionality using Tobit models, showing better false discovery rate control and power in synthetic data and real 16S rRNA and shotgun metagenomics datasets.

This paper introduces iPCR, a model that predicts patient drug responses by integrating genomic data from cell lines and tumors, showing improved performance over existing methods.

DrFARM identifies pleiotropic gene variants by jointly analyzing genetic data and controlling false discovery rate, finding 288 new metabolite associations in a metabolic study.

The paper quantifies protein levels across 32 human tissues and compares them to transcriptome data, revealing insights into post-transcriptional regulation and disease mechanisms.