Alexander Muir

This study isolates and characterizes microbiota from human pancreatic tumors and small intestine, revealing how a Klebsiella oxytoca strain affects the tumor microenvironment and therapy response.

This study shows that extracellular glutathione supports tumor growth by providing amino acids through catabolism, and inhibiting this process slows tumor growth.

This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

This study identifies mevalonate biosynthesis as a therapeutic target and biomarker for gemcitabine-resistant pancreatic cancer.

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.