Gut miRNA regulates gut microbiome and Alzheimer pathology in App-knock-in mice
Wenlin Hao, Qinghua Luo, Ilona Magdalena Szabo, Gilles Gasparoni, Sascha Tierling, Wenqiang Quan, Hsin‐Fang Chang, Gang Wu, Julia Maria Schulze-Hentrich, Yang Liu
This study shows that gut miRNA depletion in App-knock-in mice alters microbiome composition, reduces Aβ load, and induces anxiety, suggesting miRNA manipulation could influence AD pathogenesis.
bioRxiv · Jun 5, 2025 · PreprintNeuroscience