Fred B. Berry

Foxc1 and Foxc2 function in osteochondral progenitors for the progression through chondrocyte hypertrophy and mineralization of the primary ossification center.

This study investigates the roles of Foxc1 and Foxc2 in limb development, showing they are critical for chondrocyte hypertrophy and mineralization in the primary ossification center.

Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification.

This study shows that Foxc1 and Foxc2 are essential for chondrocyte differentiation and endochondral ossification, with their loss causing skeletal dysplasia and disrupted growth plate organization.

Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling

The paper shows that FOXC1 affects ciliation and cilia-dependent signaling, contributing to pleiotropic phenotypes in Axenfeld-Rieger Syndrome.

FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation.

This study shows FOXC1 inhibits BMP4 signaling by suppressing Id1 expression and SMAD activity, thereby regulating osteoblast differentiation.

foxc1a genetically interacts with ripply1 to regulate mesp-ba expression and somitogenesis in the zebrafish embryo

This study shows foxc1a and ripply1 interact to regulate mesp-ba expression and somitogenesis in zebrafish embryos, with opposing effects on mesp-ba expression and partial rescue in double knockdowns.