Tsutomu Kume

Machine-learning-based automated Schlemms canal volumetric segmentation for optical coherence tomography

This paper introduces SC-LSS, an automated tool for volumetric segmentation of Schlemms Canal in OCT images, showing high agreement with manual segmentation and detecting changes in SC size under different intraocular pressure conditions.

Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury

This study identifies FOXC1 and FOXC2 as essential regulators of intestinal regeneration after ischemia-reperfusion injury by promoting paracrine signaling from endothelial cells.

Foxc1 and Foxc2 function in osteochondral progenitors for the progression through chondrocyte hypertrophy and mineralization of the primary ossification center.

This study investigates the roles of Foxc1 and Foxc2 in limb development, showing they are critical for chondrocyte hypertrophy and mineralization in the primary ossification center.

Differential roles of neural crest- and endothelial-derived FOXC2 in trabecular meshwork and Schlemms Canal in glaucomatous pathology

The paper investigates the role of FOXC2 in neural crest- and endothelial-derived cells in the trabecular meshwork and Schlemms Canal, showing its importance in development and maintenance of the aqueous humor outflow pathway in glaucoma.

Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling

The paper shows that FOXC1 affects ciliation and cilia-dependent signaling, contributing to pleiotropic phenotypes in Axenfeld-Rieger Syndrome.