Dan Li

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway

This study shows that activating TRPML1 ion channels improves glucose uptake and reduces hyperglycemia in a T2DM mouse model by enhancing AMPK phosphorylation through the Ca2+-CaMKKβ pathway.

Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

This study shows that activating TFEB with sulforaphane reduces cholesterol accumulation in NPC1 models by enhancing lysosomal exocytosis and biogenesis.