Cell BiologybioRxivPreprint
Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway
J F Zhu, 潘召南, Shijia Wang…·Dan Li
This study shows that activating TRPML1 ion channels improves glucose uptake and reduces hyperglycemia in a T2DM mouse model by enhancing AMPK phosphorylation through the Ca2+-CaMKKβ pathway.
DOI 10.64898/2026.06.16.732532