Yuyuan Wang

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway

This study shows that activating TRPML1 ion channels improves glucose uptake and reduces hyperglycemia in a T2DM mouse model by enhancing AMPK phosphorylation through the Ca2+-CaMKKβ pathway.

Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules

This study develops GSH-responsive silica nanocapsules for systemic delivery of CRISPR components across the blood-brain barrier, achieving gene editing in the brain.

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.

Nonviral base editing of KCNJ13 mutation preserves vision in an inherited retinal channelopathy

This paper demonstrates nonviral base editing of a KCNJ13 mutation in a mouse model of retinal degeneration, preserving vision through functional rescue of Kir7.1 channels.