J F Zhu

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway

This study shows that activating TRPML1 ion channels improves glucose uptake and reduces hyperglycemia in a T2DM mouse model by enhancing AMPK phosphorylation through the Ca2+-CaMKKβ pathway.

Targeting NAT10 Activates Tumor-Intrinsic Immunity and Suppresses Tumor Progression in Head and Neck Squamous Cell Carcinoma

This study identifies NAT10 as a suppressor of tumor-intrinsic immunity in HNSCC, showing that its inhibition enhances immune responses and suppresses tumor progression.

Placental invasion mismatch underlines pregnancy disorders and cancers

The paper identifies conserved regulatory programs in placental invasion across mammals and links their dysregulation to pregnancy disorders and cancers.

Effect of CSFV on Differential Genes of Histone Lactylation at H3K18 in the PI3K-AKT Signaling Pathway

This study investigates how CSFV affects histone lactylation at H3K18 in the PI3K-AKT pathway, identifying 10 differential genes and showing increased THBS4 expression.

Scaffold-Lab: Critical Evaluation and Ranking of Protein Backbone Generation Methods in A Unified Framework

The paper evaluates and ranks protein backbone generation methods using a unified benchmark, identifying top-performing models in both unconditional and conditional generation.