Statistical crystallography reveals an allosteric network in SARS-CoV-2 Mpro
Anne Creon, Emilie Scheer, Patrick Y. A. Reinke, Aida Rahmani Mashhour, Sebastian Günther, Stephan Niebling, Kira Schamoni-Kast, Charlotte Uetrecht, Alke Meents, Henry N. Chapman, Janina Sprenger, Thomas J. Lane
The paper uses statistical crystallography to model correlated motions in SARS-CoV-2 Mpro and shows how dimerization affects catalytic activity through structural links.
Communications Biology · May 2, 2026Peer-reviewedBiochemistry