Thomas J. Lane

The paper uses X-ray crystallography to observe intermediates in DNA repair by (6-4) photolyase, revealing an oxetane species and a hemi-cleaved intermediate.

The paper uses statistical crystallography to model correlated motions in SARS-CoV-2 Mpro and shows how dimerization affects catalytic activity through structural links.

This paper improves difference map quality in protein crystallography by using negentropy and total variation denoising to better detect low-occupancy states.