Weidong Le

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

This study investigates the functional roles of two nigrostriatal dopaminergic neuron subtypes in motor and associative learning using genetic and chemogenetic approaches in mice.

This study shows JMJD3 deficiency in midbrain dopamine neurons reduces dopamine levels and worsens chronic inflammatory pain.

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.