CDK/mTOR-dependent phosphorylation of UBE2H restrains its charging with ubiquitin and regulates CTLH-dependent degradation
Yingqian Chen, Valentina Rossio, João A. Paulo, Menuka Karki, Sandhya Manohar, Noelle Ozimek, Laura Frizzi, Steven P. Gygi, Randall W. King
The paper identifies CDK/mTOR-dependent phosphorylation of UBE2H as a regulator of CTLH E3 ligase activity, showing how it controls ubiquitylation and substrate degradation.
bioRxiv · Mar 9, 2026 · PreprintCell Biology