Sandhya Manohar

This study shows that excess cell size drives senescence by altering mRNA homeostasis and reorganizing the genome, leading to the secretory phenotype and cell cycle arrest.

The paper identifies CDK/mTOR-dependent phosphorylation of UBE2H as a regulator of CTLH E3 ligase activity, showing how it controls ubiquitylation and substrate degradation.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

The paper shows that K63 ubiquitin chains accumulate in non-cytosolic compartments during oxidative stress and that VCP/p97 and NPLOC4 regulate their localization and removal.

The paper re-analyzes protein half-life data in yeast to provide consistent estimates, finding that protein stability correlates with abundance and function.