Author

Laura R. Ganser

Johns Hopkins UniversityORCID 0000-0002-7357-4588Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James ShorteriD· 2 shared Sua MyongiD· 2 shared Aaron D. GitleriD· 1 shared Aaron R. HaeusleriD· 1 shared Adam BrineriD· 1 shared Beryl B. CummingsiD· 1 shared Björn OskarssoniD· 1 shared Bradley F. BoeveiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

James ShorterORCID

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2 papers

Recent·Most cited

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation

Jenny L. Carey, Miyuki Hayashi, Emily M. Welebob, Laura R. Ganser, Huan Wang, Kerry Buckhaults, Jacquelyn A. DePierro, Zheng Shi, James Shorter, Sua Myong, Aaron R. Haeusler, Lin E. Guo

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

Nucleic Acids Research · Jun 4, 2026Peer-reviewedBiochemistry

TDP-43 represses cryptic exon inclusion in FTD/ALS gene UNC13A

X. Rosa Ma, Mercedes Prudencio, Yuka Mitsuhashi Koike, Sarat C. Vatsavayai, Garam Kım, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, Hermann Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, , Aaron D. Gitler

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.

Nature · Feb 23, 2022Peer-reviewedNeuroscience