Author

Jacquelyn A. DePierro

Thomas Jefferson University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1

Frequent Co-Authors

Lin E. GuoiD· 2 shared Miyuki HayashiiD· 2 shared Aaron R. HaeusleriD· 1 shared Amandeep GirdhariD· 1 shared Brigid K. JenseniD· 1 shared Emily M. Welebob· 1 shared Gino CingolaniiD· 1 shared Huan WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Lin E. GuoORCID

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2 papers

Recent·Most cited

Engineered Chimeric Proteins Functionally Replace ALS-causing Endogenous FUS and TDP-43 to Improve Neuronal Health

Miyuki Hayashi, Brigid K. Jensen, Amandeep Girdhar, Shashirekha S. Markandaiah, Ying‐Hui Ko, Nikhita Arunprakash, Jacquelyn A. DePierro, Tengyang Ni, Wenjing Li, Weixing Zhao, Gino Cingolani, Piera Pasinelli, Lin E. Guo

The paper engineers chimeric proteins to replace ALS-causing FUS and TDP-43, improving neuronal health by reducing aggregation and restoring nuclear functions.

bioRxiv · Oct 8, 2026 · PreprintNeuroscience

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation

Jenny L. Carey, Miyuki Hayashi, Emily M. Welebob, Laura R. Ganser, Huan Wang, Kerry Buckhaults, Jacquelyn A. DePierro, Zheng Shi, James Shorter, Sua Myong, Aaron R. Haeusler, Lin E. Guo

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

Nucleic Acids Research · Jun 4, 2026Peer-reviewedBiochemistry