Patrick Ruther

Multichannel optical cochlear implants enable spectrally distinct auditory activity

This paper demonstrates that multichannel optical cochlear implants (oCIs) with ChReef enable improved spectral resolution compared to electrical stimulation in gerbils.

Friend, not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants

This study compares tissue reactivity to stiff silicon and flexible polyimide implants in mice, finding that flexible polyimide reduces lesions and immune response.

Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system

This paper develops a low-weight, wireless optogenetic cochlear implant system for hearing restoration in deafened rats, demonstrating its ability to enable locomotion tasks in response to acoustic stimulation.

Layer-specific stimulations of parvalbumin-positive cortical interneurons in mice entrain brain rhythms to different frequencies

The paper shows that stimulating parvalbumin-positive interneurons in specific cortical layers of awake mice can entrain local field potentials at different frequencies depending on the layer.

Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation

This paper develops thin optical fibers and integration techniques to enable large-scale neuronal recordings and ultrafast optogenetic inhibition in freely moving animals.

Intracortical probe arrays with silicon backbone and microelectrodes on thin polyimide wings enable long-term stable recordings in vivo

This paper develops a new neural probe with a silicon backbone and thin polyimide wings for long-term stable in vivo recordings in mice.

Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats

This paper introduces a multifunctional optrode for optogenetics, enabling simultaneous drug delivery, optical stimulation, and electrophysiological recording in freely moving rats.

Recording site placement on planar silicon-based probes affects neural signal quality: edge sites enhance acute recording performance

The paper investigates how the placement of recording sites on silicon probes affects neural signal quality, finding edge sites provide better signal quality than center sites in acute recordings.

Why not record from every electrode with a CMOS scanning probe?

This paper introduces a high-density CMOS scanning probe for neural recording, demonstrating its ability to capture neural activity across multiple brain regions with improved resolution compared to lower density devices.