The paper conducts an epigenome-wide association study of serum folate in maternal blood, identifying three CpG sites associated with folate levels and some cardiometabolic traits.

Epigenomics · Jan 1, 2023Peer-reviewedGenetic & Genomic Medicine

Cohort Profile: Epigenetics in Pregnancy (EPIPREG)-population-based sample of European and South Asian pregnant women living in Norway with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

Nicolás Fragoso-Bargas, Julia O. Opsahl, Nadezhda Kiryushchenko, Yvonne Böttcher, Sindre Lee-Ødegård, Elisabeth Qvigstad, Kåre Rønn Richardsen, Christin Wiegels Waage, Line Sletner, Anne Karen Jenum, Rashmi B. Prasad, Leif Groop, Gunn-Helen Moen, Kåre I. Birkeland, Christine Sommer

EPIPREG collects DNA methylation data from pregnant women in Norway to study associations with cardiometabolic traits and ethnic disparities in health.

PLoS ONE · Aug 13, 2021Peer-reviewedGenetic & Genomic Medicine

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

Gunn-Helen Moen, Robin N. Beaumont, Niels Grarup, Christine Sommer, Beverley M. Shields, Debbie A. Lawlor, Rachel M. Freathy, David M. Evans, Nicole M. Warrington

This study uses Mendelian Randomization to assess the causal effect of maternal vitamin B12 and folate on offspring birthweight, finding a positive causal effect for folate but not for B12.

International Journal of Epidemiology · Nov 19, 2020Peer-reviewedGenetics