The paper develops a polygenic score for dizygotic twinning, showing it explains 1.6% of liability variance and is linked to fertility outcomes and genetic correlations with related conditions.

Journal of Assisted Reproduction and Genetics · May 26, 2025Peer-reviewedGenetic & Genomic Medicine

Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence

Mona Bekkhus, Stella Tsotsi, Christian Magnus Page, Nikolai Olavi Czajkowski, W. Liu, Espen Røysamb, Nes R. Bang, A. Oftedal, Robert Lyle, Laurie J. Hannigan, Ole A. Andreassen, Yunpeng Wang

The paper investigates the genetic and epigenetic factors underlying childhood internalizing and externalizing problems and their co-occurrence using GWAS, PGS, and EWAS in a large cohort.

medRxiv · May 24, 2025 · PreprintGenetic & Genomic Medicine

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese, Matthew J Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrušaitytė, Syed Hasan Arshad, Marian J. Bakermans‐Kranenburg, Lawrence Joseph Beilin, Carrie V. Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, , Charlotte A. M. Cecil

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

medRxiv · Feb 29, 2024 · PreprintGenetic & Genomic Medicine

Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Nicolás Fragoso-Bargas, Christian Magnus Page, Bonnie R. Joubert, Stephanie J. London, Sindre Lee-Ødegård, Julia O. Opsahl, Line Sletner, Anne Karen Jenum, Elisabeth Qvigstad, Rashmi B. Prasad, Gunn-Helen Moen, Kåre I. Birkeland, Christine Sommer

The paper conducts an epigenome-wide association study of serum folate in maternal blood, identifying three CpG sites associated with folate levels and some cardiometabolic traits.

Epigenomics · Jan 1, 2023Peer-reviewedGenetic & Genomic Medicine

The X-factor in ART: does the use of Assisted Reproductive Technologies influence DNA methylation on the X chromosome?

Julia Romanowska, Haakon E. Nustad, Christian Magnus Page, William R. P. Denault, Jon Bohlin, Yunsung Lee, Maria Christine Magnus, Kristine Løkås Haftorn, Miriam Gjerdevik, Boris Novakovic, Richard Saffery, Håkon Kristian Gjessing, Robert Lyle, Per Minor Magnus, Siri E. Håberg, Astanand Jugessur

This study investigates DNA methylation differences on the X chromosome in ART-conceived versus naturally-conceived newborns, finding sex-specific methylation changes linked to neurodevelopmental processes.

bioRxiv · Oct 6, 2022 · PreprintGenetics

Cross-fitted instrument: a blueprint for one-sample Mendelian Randomization

William R. P. Denault, Jon Bohlin, Christian Magnus Page, Stephen Burgess, Astanand Jugessur

This paper introduces a new method for one-sample Mendelian Randomization that reduces bias from weak instruments and enables cross-ethnic analysis.

PLoS Computational Biology · Aug 29, 2022Peer-reviewedBioinformatics

Variably methylated regions in the newborn epigenome: environmental, genetic and combined influences

Darina Czamara, Gökçen Eraslan, Christian Magnus Page, Jari M. T. Lahti, Marius Lahti‐Pulkkinen, Esa K Hämäläinen, Eero Kajantie, Hannele M. Laivuori, Pia Villa, Rebecca M. Reynolds, Wenche Nystad, Siri E. Håberg, Stephanie J. London, Kieran J. O’Donnell, Elika Garg, , Robert M. Maier

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

Nature Communications · Jun 11, 2019Peer-reviewedGenetics