IspE Kinase as an Anti-infective Target: Role of a Hydrophobic Pocket in Inhibitor Binding
Rawia Hamid, Danica J. Walsh, Eleonora Diamanti, Diana Aguilar, Antoine Lacour, Mostafa M. Hamed, Anna K. H. Hirsch
The paper investigates IspE kinase homologs from pathogenic bacteria, identifies structural differences affecting inhibitor binding, and highlights a hydrophobic pocket critical for inhibitor specificity in Acinetobacter baumannii.
Structure · Nov 6, 2024Peer-reviewedBiophysics