Antoine Lacour

The paper investigates IspE kinase homologs from pathogenic bacteria, identifies structural differences affecting inhibitor binding, and highlights a hydrophobic pocket critical for inhibitor specificity in Acinetobacter baumannii.

The paper presents high-resolution crystal structures of DXPS from Pseudomonas aeruginosa and Klebsiella pneumoniae in different forms, revealing conformational changes upon cofactor binding and providing insights for drug design.