Author

David L. Gillespie

University of UtahORCID 0000-0002-7375-0262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Randy L. JenseniD· 2 shared Abigail G ParrishiD· 1 shared Carmine Schiavone· 1 shared David Austin NixiD· 1 shared Dylan J Keiser· 1 shared Esther NeediD· 1 shared Frank SzulzewskyiD· 1 shared Howard ColmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Randy L. JensenORCID

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2 papers

Recent·Most cited

Comprehensive analysis of TEAD inhibition in meningioma identifies MEK and mTOR inhibition as effective combination therapies against resistant lines.

Dylan J Keiser, Meghan S Buddy, Solmaz Mojarad-Jabali, Qing Li, Missia Kohler-Skinner, Abigail G Parrish, David L. Gillespie, David Austin Nix, Sheri L. Holmen, Howard Colman, William Couldwell, Randy L. Jensen, Frank Szulzewsky

This study identifies TEAD inhibition as a therapeutic target in meningioma and shows that combining MEK and mTOR inhibition overcomes resistance in resistant lines.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

Image-Guided Targeting of Mitochondrial Metabolism Sensitizes Pediatric Malignant Rhabdoid Tumors to Low Dose Radiotherapy

Wenxi Xia, Matthew Goff, Carmine Schiavone, Neetu Singh, Jiemin Huang, Esther Need, Joseph Cave, David L. Gillespie, Randy L. Jensen, Marty D. Pagel, Prashant Dogra, Sixiang Shi, Shreya Goel

This study shows that targeting mitochondrial metabolism with Atovaquone enhances radiotherapy effectiveness in pediatric rhabdoid tumors by improving tumor oxygenation.

Science Advances · May 23, 2025Peer-reviewedBioengineering