Sheri L. Holmen

This paper demonstrates that ultrasound-triggered chemotherapy improves survival in a glioblastoma model by enabling localized drug release at the tumor site.

This study identifies RAS(ON) inhibitors effective against NRAS-mutated melanoma and reveals resistance mechanisms through Ppia and Map2k1 mutations.

This study identifies TEAD inhibition as a therapeutic target in meningioma and shows that combining MEK and mTOR inhibition overcomes resistance in resistant lines.

This study shows FAK promotes metastasis in BRAF-mutant melanoma through kinase-dependent mechanisms downstream of PTEN, suggesting FAK inhibition could improve treatment outcomes.

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

This study shows that oxidative phosphorylation (OXPHOS) is critical for melanoma metastasis to the lungs and brain, based on analysis of human patients and mouse models.