Peter Bor‐Chian Lin

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

This study shows that reducing Hexokinase 2 (HK2) in microglia slows Alzheimer's disease progression, but complete loss worsens inflammation, suggesting a complex role for HK2 in neuroinflammation.

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

This study shows INPP5D expression increases in Alzheimer's disease, particularly in plaque-associated microglia, and suggests it may be a risk factor and therapeutic target.

The paper identifies a rare PLCG2 variant that increases Alzheimer's disease risk and shows increased PLCG2 expression correlates with amyloid deposition in AD patients.