Author

Carolien A. M. Koeleman

Leiden University Medical CenterORCID 0000-0002-7402-6380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Approach:statistical model· 1

Frequent Co-Authors

Manfred WuhreriD· 2 shared Agnes L. Hipgrave EderveeniD· 1 shared Albert BondtiD· 1 shared Alessia ViscontiiD· 1 shared Anna HalamaiD· 1 shared Arif Bülent EkiciiD· 1 shared Bernd M. Spriewald· 1 shared David FalckiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Manfred WuhrerORCID

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2 papers

Recent·Most cited

IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression

David Falck, Maria V Sokolova, Carolien A. M. Koeleman, Vanessa Irumva, Philipp Kirchner, Sebastian R. Schulz, Katja G. Schmidt, Thomas Harrer, Arif Bülent Ekici, Bernd M. Spriewald, Georg Andreas Schett, Manfred Wuhrer, Martin Herrmann i, Ulrike Steffen

The paper compares glycosylation patterns of IgA1 and IgA2, finding subclass-specific differences despite similar glycosylation enzyme expression.

Cell Communication and Signaling · Feb 17, 2025Peer-reviewedImmunology

The genetics and epidemiology of N- and O- IgA glycomics

Alessia Visconti, Niccolò Rossi, Albert Bondt, Agnes L. Hipgrave Ederveen, Gaurav Thareja, Carolien A. M. Koeleman, Nisha Stephan, Anna Halama, Hannah J. Lomax-Browne, Matthew Caleb Pickering, Shu‐Feng Zhou, Manfred Wuhrer, Karsten Suhre, Mario Falchi

This study presents the first large-scale IgA glycomics dataset from twins, identifies shared and specific genetic loci influencing IgA and IgG glycosylation, and shows genetic conservation across ethnicities.

medRxiv · Jan 5, 2024 · PreprintGenetic & Genomic Medicine