Eli J. Costa

The paper shows that single-cell gene expression responses in mammalian systems are all-or-none due to stable epigenetic variability, not bursty transcription or bistability.

This paper identifies bifunctional transcriptional effector domains that generate gene expression pulses by switching from activation to repression based on DNA occupancy, and develops a kinetic model to program cell states.

The paper identifies that differential nuclear import timing controls gene expression onset in early embryonic development by regulating protein access to the genome.

The paper quantifies protein turnover in E. coli under 12 conditions, revealing cytoplasmic protein recycling under nitrogen limitation and identifying unknown proteolysis pathways.