Alex N. T. Johnson

Expanding Targeted Instrumentation for Discovery Applications: Complement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument

This paper demonstrates that a quadrupole-ion trap instrument can perform multiplexed shotgun proteomics with accuracy comparable to a dedicated tribrid instrument, offering a cost-effective alternative.

Super-resolution mass spectrometry enables rapid, accurate, and highly-multiplexed proteomics at the MS2-level

The paper demonstrates that super-resolution mass spectrometry with least-squares fitting enables highly-multiplexed, accurate, and precise shotgun proteomics at the MS2 level.

Global Protein-Turnover Quantification in Escherichia coli Reveals Cytoplasmic Recycling under Nitrogen-Limitation

The paper quantifies protein turnover in E. coli under 12 conditions, revealing cytoplasmic protein recycling under nitrogen limitation and identifying unknown proteolysis pathways.

TMTPro Complementary Ion Quantification Increases Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 Level

This paper introduces TMTProC, an optimized complementary ion quantification method for TMTPro tags, improving sensitivity and accuracy in multiplexed proteomics.