Cecelia J. Andrews

The paper shows that single-cell gene expression responses in mammalian systems are all-or-none due to stable epigenetic variability, not bursty transcription or bistability.

This paper identifies bifunctional transcriptional effector domains that generate gene expression pulses by switching from activation to repression based on DNA occupancy, and develops a kinetic model to program cell states.

The paper identifies hundreds of RNA-regulatory effectors in human RBPs using HT-RNA-Recruit and develops a synthetic RNA regulator with a predictive mathematical model.

The paper measures how combinations of transcriptional activators and repressors affect gene expression and uses this to create a tunable synthetic transcription factor.

The paper identifies nSMase2 as a critical regulator of developmental EMT by inducing endocytosis to activate Wnt and BMP signaling during neural crest migration.

The paper systematically maps and characterizes transcriptional effector domains in human chromatin regulators and transcription factors, identifying new activation and repression domains and their functional features.