Diogo V. M. Melo

Covalent bond formation caught in a LOV photoreceptor

This paper resolves the mechanism of covalent bond formation in a LOV photoreceptor using time-resolved crystallography and spectroscopy, revealing a water-mediated proton transfer that accelerates the reaction by fourteen orders of magnitude.

Aerosol delivery-based serial femtosecond crystallography

This paper introduces an aerosol delivery method for serial femtosecond crystallography that reduces background scattering and improves data quality, validated with a 1.9 Å resolution structure of Cydia pomonella granulovirus nanocrystals.

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.