Caitlin E. Hatton

Best practices for cryo-trapping time-resolvedcrystallography with the Spitrobot crystal plunger

This paper describes a protocol for cryo-trapping time-resolved crystallography using automated crystal plungers to study enzyme reaction pathways at millisecond resolution.

SPITROBOT-2 advances time-resolved cryo-trapping crystallography to under 25 ms

SPITROBOT-2 improves cryo-trapping crystallography with a 23 ms delay, reducing sample preparation time to three minutes per sample.

A mutation at the dimer interface regulates catalysis

This study shows that subtle mutations at the dimer interface of FAcD affect enzyme activity by disrupting hydrogen-bonding networks and altering dimer stability.

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.