Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.
Nazzareno Cannella, Stefano Tambalo, Veronica Lunerti…·Roberto Ciccocioppo
This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.