Author

Nazzareno Cannella

Università di CamerinoORCID 0000-0002-2891-8679Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:rat· 4 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brittany N. KuhniD· 4 shared Peter W. KalivasiD· 4 shared Roberto CiccocioppoiD· 4 shared Abraham A. PalmeriD· 3 shared Analyse T. RobertsiD· 3 shared Ayteria D. CrowiD· 3 shared Dongjun ChungiD· 3 shared Eric DereschewitziD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Brittany N. KuhnORCID

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4 papers

Recent·Most cited

Genomic SEM reveals shared genetic architecture and expands locus discovery for locomotor activity in heterogeneous stock rats

Apurva S. Chitre, Thiago Missfeldt Sanches, Gavrila Ang, Nana K. Amissah, Rodolfo Avila, Hannah V. Bimschleger, Paola Campo, Nazzareno Cannella, Denghui Chen, Riyan Cheng, Katarina A Cohen, Ayteria D. Crow, Eric Dereschewitz, Michelle R. Doyle, Maya Eid, , Abraham A. Palmer

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

bioRxiv · Oct 6, 2026 · PreprintGenetics

Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats

Brittany N. Kuhn, Nazzareno Cannella, Apurva S. Chitre, Khai‐Minh Nguyen, Katarina A Cohen, Denghui Chen, Beverly F Peng, Kendra S Ziegler, Bonnie Lin, Benjamin B. Johnson, Thiago Missfeldt Sanches, Ayteria D. Crow, Veronica Lunerti, Arkobrato Gupta, Eric Dereschewitz, , Abraham A. Palmer

This study identifies genetic loci associated with opioid use disorder-related behaviors in rats using a genome-wide association approach and network-based clustering.

Molecular Psychiatry · Feb 25, 2025Peer-reviewedGenetics

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliency

Brittany N. Kuhn, Nazzareno Cannella, Ayteria D. Crow, Veronica Lunerti, Arkobrato Gupta, Stephen J. Walterhouse, Carter Allen, Reda Chalhoub, Eric Dereschewitz, Analyse T. Roberts, Mackenzie Cockerham, Angela Beeson, Rusty W. Nall, Abraham A. Palmer, Gary Hardiman, , Peter W. Kalivas

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

American Journal of Psychiatry · Jan 15, 2025Peer-reviewedNeuroscience

Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.

Nazzareno Cannella, Stefano Tambalo, Veronica Lunerti, Giulia Scuppa, Luisa de Vivo, Sarah Abdulmalek, Analia Kinen, James Mackle, Brittany N. Kuhn, Leah C. Solberg Woods, Dongjun Chung, Peter W. Kalivas, Laura Soverchia, Massimo Ubaldi, Gary Hardiman, , Roberto Ciccocioppo

This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.

Brain Behavior and Immunity · Mar 5, 2024Peer-reviewedNeuroscience