Brittany N. Kuhn

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

This study identifies genetic loci associated with opioid use disorder-related behaviors in rats using a genome-wide association approach and network-based clustering.

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.

The paper shows that inhibiting the PrL-PVT pathway reduces cue-induced relapse in ST rats but not GT rats, highlighting individual differences in relapse vulnerability.

This study investigates the role of the lateral hypothalamus and orexinergic signaling in the paraventricular thalamus in attributing incentive salience to reward cues using Pavlovian conditioned approach behavior in rats.

This study shows that the PrL-PVT pathway modulates incentive value attribution to reward-cues in rats, with distinct effects in sign-trackers and goal-trackers.