Author

Yonatan Ayalew Mekonnen

Moffitt Cancer CenterORCID 0000-0002-7430-9428Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:metabolomics· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Elsa Renee FloresiD· 3 shared Hayley D. AckermaniD· 3 shared Paul A. StewartiD· 3 shared Ashley LuiiD· 2 shared Augustine Takyi· 2 shared Brooke L. FridleyiD· 2 shared Isis Yanina Narvaez-BanderaiD· 2 shared John Koomen· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBioinformatics

Elsa Renee FloresORCID

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4 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 3, 2026

spatialMET: an open and scalable framework for spatial metabolomics analysis

Yonatan Ayalew Mekonnen, Oscar Ospina, Vanessa Rubio…·Paul A. Stewart

spatialMET provides a scalable, open-source framework for end-to-end spatial metabolomics analysis, identifying spatial domains and differential metabolites in mouse cancer data.

DOI 10.64898/2026.08.27.747606

mousemetabolomics

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedJan 15, 2026

iModMix: Integrative Module Analysis for Multi-omics Data

Isis Yanina Narvaez-Bandera, Ashley Lui, Yonatan Ayalew Mekonnen…·Paul A. Stewart

iModMix identifies novel multi-omics associations by constructing data-driven modules without relying on biological annotations.

3 citations

proteomicsmetabolomics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintAug 28, 2025

EnrichMET: R Package for Integrated Pathway and Network Analysis for Metabolomics

Yonatan Ayalew Mekonnen, Neha Dhake, Vanessa Y. Rubio…·Paul A. Stewart

EnrichMET provides an R package for fast and reproducible pathway enrichment analysis in metabolomics, supporting multiple methods and offering both command-line and Shiny interfaces.

DOI 10.1101/2025.08.28.672951

metabolomicsstatistical model

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintMar 27, 2024

Epigenetic Reprogramming Mediates Monocyte and Heterologous T Cell-derived Cytokine Responses after BCG Vaccination

Cancan Qi, Zhaoli Liu, Gizem Kılıç…·Cheng‐Jian Xu

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

4 citations

humanDNA methylation

𝕏 PostBluesky