Alexandra B. Byrne

Nidogen/NID-1 guides regenerating motor axons in the mature nervous system

This study identifies NID-1 as a guidance cue for regenerating motor axons in C. elegans, showing its role in axon navigation and synapse reformation.

Inhibiting Clarinet/CLA-1 restores function to injured motor neurons

This study shows that inhibiting Clarinet/CLA-1 in C. elegans enhances axon regeneration without affecting synapse reformation, suggesting a potential therapeutic target for nerve repair.

Comamonas aquatica inhibits TIR-1/SARM1 induced axon degeneration

This study identifies Comamonas aquatica as a neuroprotective bacterium that prevents axon degeneration by providing Vitamin B12 to reduce homocysteine toxicity in C. elegans.

PARP knockdown promotes synapse reformation after axon injury

This study shows that PARP inhibition enhances synapse reformation in regenerating axons, improving functional recovery after axon injury.

A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission

This study shows how a single neuron in C. elegans uses multiple transmission modes to coordinate different motor behaviors during egg-laying.

TIR-1/SARM1 Inhibits Axon Regeneration

This study identifies TIR-1/SARM1 as a dual regulator that inhibits axon regeneration while promoting degeneration, revealing distinct pathways for each function.