This study identifies Comamonas aquatica as a neuroprotective bacterium that prevents axon degeneration by providing Vitamin B12 to reduce homocysteine toxicity in C. elegans.

bioRxiv · Nov 20, 2024 · PreprintNeuroscience

TIR-1/SARM1 Inhibits Axon Regeneration

Victoria L Czech, Lauren O'Connor, Brendan Philippon, Emily K. Norman, Alexandra B. Byrne

This study identifies TIR-1/SARM1 as a dual regulator that inhibits axon regeneration while promoting degeneration, revealing distinct pathways for each function.

eLife · Feb 1, 2023Peer-reviewedNeuroscience

Dopamine transporter trafficking and Rit2 GTPase: In vivo impact and mechanism of action

Rita R. Fagan, Patrick J. Kearney, Carolyn G. Sweeney, Dino Luethi, Florianne E. Schoot Uiterkamp, Klaus W. Schicker, Brian S. Alejandro, Lauren O'Connor, Harald H. Sitte, Haley E. Melikian

This study investigates the role of Rit2 GTPase in PKC-stimulated dopamine transporter (DAT) endocytosis in DAergic terminals, revealing region- and sex-specific differences.

Journal of Biological Chemistry · Mar 4, 2020Peer-reviewedNeuroscience