Author

Khoa Ngo

University of California SystemORCID 0000-0002-7454-2924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Assay:electronic health records· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Colleen E. ClancyiD· 2 shared Igor V. VorobyoviD· 2 shared Vladimir M. Yarov-YarovoyiD· 2 shared Jon T. SackiD· 1 shared Kazuharu FurutaniiD· 1 shared Matthew James MarquisiD· 1 shared Pei‐Chi YangiD· 1 shared Satomi KitaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

Colleen E. ClancyORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJun 3, 2026

A hERG Blocker Facilitates K+ Channel Current by Agonizing Pore Opening while Blocking

Steffen S. Docken, Matthew James Marquis, Khoa Ngo…·Jon T. Sack

The paper investigates how hERG blockers like nifekalant can increase K+ channel current through an agonism-while-blocking mechanism, potentially explaining their safety profile.

DOI 10.64898/2026.05.30.728541

humanelectronic health records

𝕏 PostBluesky

BiophysicsbioRxivJan 27, 2024

Harnessing AlphaFold to reveal hERG channel conformational state secrets

Khoa Ngo, Pei‐Chi Yang, Vladimir M. Yarov-Yarovoy…·Igor V. Vorobyov

This paper uses AlphaFold to predict discrete conformational states of hERG channels, revealing structural features and drug interactions that improve drug safety screening.

19 citations

humanprotein structure

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