A hERG Blocker Facilitates K+ Channel Current by Agonizing Pore Opening while Blocking
Steffen S. Docken, Matthew James Marquis, Khoa Ngo, Yuumu Wada, Satomi Kita, Vladimir M. Yarov-Yarovoy, Colleen E. Clancy, Igor V. Vorobyov, Timothy J. Lewis, Kazuharu Furutani, Jon T. Sack
The paper investigates how hERG blockers like nifekalant can increase K+ channel current through an agonism-while-blocking mechanism, potentially explaining their safety profile.
bioRxiv · Jun 3, 2026 · PreprintPharmacology & Toxicology